Cellular research
NAD+ precursors
Trials and reviews describe nicotinamide mononucleotide and nicotinamide riboside as precursors that feed the NAD+ salvage pathway, with NAD+ then serving as a substrate the sirtuin and PARP enzymes consume.
What PubMed contains
Each figure links to the query that produced it. Where a count is zero, the published evidence of that kind was absent from the index at the retrieval date — a fact about the literature, not a judgement of ours.
Selected literature
Published work on NAD+ precursors
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
Clinical trialYi L et al. 2023GeroSciencePMID 36482258
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
ReviewSong Q et al. 2023Advances in nutrition (Bethesda, Md.)PMID 37619764
Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns
ReviewNadeeshani H et al. 2022Journal of advanced researchPMID 35499054
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Clinical trialYoshino M et al. 2021Science (New York, N.Y.)PMID 33888596
NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health
ReviewAlegre GFS et al. 2023Current nutrition reportsPMID 37273100
What is really known about the effects of nicotinamide riboside supplementation in humans
ReviewDamgaard MV et al. 2023Science advancesPMID 37478182
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Clinical trialConze D et al. 2019Scientific reportsPMID 31278280
Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges
ReviewWang E et al. 2025BiogerontologyPMID 40550930
Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men
Clinical trialIrie J et al. 2020Endocrine journalPMID 31685720
Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study
Clinical trialLiao B et al. 2021Journal of the International Society of Sports NutritionPMID 34238308
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
Clinical trialOrr ME et al. 2024GeroSciencePMID 37994989
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
Clinical trialNorheim KL et al. 2024Nature agingPMID 39548320
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Provided for navigation. The literature above concerns a compound class as the published record describes it; it is not a representation about any product we sell, and no listing below has been evaluated against the research on this page.
This page is a bibliographic reference for research professionals. It is educational only, it is not medical, clinical, or legal advice, and it is not a recommendation to use any compound. Peptide research is an evolving field: counts and conclusions change as new work is published. Readers are responsible for evaluating the primary literature themselves and for consulting qualified professionals in their own jurisdiction.