Cellular research
Epithalon (AEDG)
The indexed literature describes a small synthetic peptide (a tetrapeptide) studied as a regulator linked to the pineal gland, with reported effects on telomerase expression in laboratory models.
What PubMed contains
Each figure links to the query that produced it. Where a count is zero, the published evidence of that kind was absent from the index at the retrieval date — a fact about the literature, not a judgement of ours.
Selected literature
Published work on Epithalon (AEDG)
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
ReviewAraj SK et al. 2025International journal of molecular sciencesPMID 40141333
Peptides and Ageing
ReviewKhavinson VKh 2002Neuro endocrinology lettersPMID 12374906
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
StudyKhavinson V et al. 2020Molecules (Basel, Switzerland)PMID 32019204
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
StudyAl-Dulaimi S et al. 2025BiogerontologyPMID 40908429
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
StudyGatta M et al. 2025Stem cell reviews and reportsPMID 40493162
Short Peptides Protect Oral Stem Cells from Ageing
StudySinjari B et al. 2020Stem cell reviews and reportsPMID 31677028
Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland
StudyKhavinson VK et al. 2017Bulletin of experimental biology and medicinePMID 29124531
[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]
StudyIvko OM et al. 2020Advances in gerontology = Uspekhi gerontologiiPMID 33280326
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
StudyYue X et al. 2022AgingPMID 35413689
[Aging of the pineal gland]
StudyKhavinson VKh et al. 2002Advances in gerontology = Uspekhi gerontologiiPMID 12096440
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice
StudyKossoy G et al. 2006In vivo (Athens, Greece)PMID 16634527
Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
StudyAnisimov VN et al. 2002International journal of cancerPMID 12209581
Research areas
Where this sits in the field
Related topics
Others indexed under cellular research
Catalogue
Listings under this name
Provided for navigation. The literature above concerns a compound class as the published record describes it; it is not a representation about any product we sell, and no listing below has been evaluated against the research on this page.
This page is a bibliographic reference for research professionals. It is educational only, it is not medical, clinical, or legal advice, and it is not a recommendation to use any compound. Peptide research is an evolving field: counts and conclusions change as new work is published. Readers are responsible for evaluating the primary literature themselves and for consulting qualified professionals in their own jurisdiction.