Cellular research
GHK-Cu
Published reviews describe a small copper-binding peptide (a tripeptide) present naturally in human blood, reporting effects on gene expression and collagen synthesis.
What PubMed contains
Each figure links to the query that produced it. Where a count is zero, the published evidence of that kind was absent from the index at the retrieval date — a fact about the literature, not a judgement of ours.
Selected literature
Published work on GHK-Cu
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
ReviewPickart L et al. 2018International journal of molecular sciencesPMID 29986520
The potential of GHK as an anti-aging peptide
StudyDou Y et al. 2020Aging pathobiology and therapeuticsPMID 35083444
Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective
ReviewMortazavi SM et al. 2025BioImpacts : BIPMID 39963574
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
ReviewPickart L et al. 2015BioMed research internationalPMID 26236730
Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway
StudyDeng M et al. 2023Journal of cachexia, sarcopenia and musclePMID 36905132
The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6
StudyBian Y et al. 2024Redox biologyPMID 38879894
Glycyl-L-histidyl-L-lysine-Cu2(+) (GHK-Cu) Attenuates CuSO(4) or LPS induced-inflammation in Zebrafish larvae model
StudyHu J et al. 2026European journal of pharmacologyPMID 41997403
Glycyl-L-histidyl-L-lysine-Cu(2+) attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway
StudyZhang Q et al. 2022Frontiers in molecular biosciencesPMID 35936787
Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms
StudyMao S et al. 2025Frontiers in pharmacologyPMID 40672369
An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant
StudyHu D et al. 2025Colloids and surfaces. B, BiointerfacesPMID 40716276
Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex via activation of SIRT1 in airway epithelial cells
StudyZhang Q et al. 2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapiePMID 37257226
Phenothiazine-Based Cu(II)-Selective Fluorescent Sensor: GHK-Cu Sensing Applications
StudySahu R et al. 2023The Journal of organic chemistryPMID 37830186
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Provided for navigation. The literature above concerns a compound class as the published record describes it; it is not a representation about any product we sell, and no listing below has been evaluated against the research on this page.
This page is a bibliographic reference for research professionals. It is educational only, it is not medical, clinical, or legal advice, and it is not a recommendation to use any compound. Peptide research is an evolving field: counts and conclusions change as new work is published. Readers are responsible for evaluating the primary literature themselves and for consulting qualified professionals in their own jurisdiction.