Metabolic research
MOTS-c
Reviews describe MOTS-c as a peptide encoded in mitochondrial DNA rather than the cell nucleus, and report activation of the energy-sensing enzyme AMPK and regulation of the folate–methionine cycle in laboratory models.
What PubMed contains
Each figure links to the query that produced it. Where a count is zero, the published evidence of that kind was absent from the index at the retrieval date — a fact about the literature, not a judgement of ours.
Selected literature
Published work on MOTS-c
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
ReviewZheng Y et al. 2023Frontiers in endocrinologyPMID 36761202
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
StudyLee C et al. 2015Cell metabolismPMID 25738459
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination
StudyYin Y et al. 2024Advanced science (Weinheim, Baden-Wurttemberg, Germany)PMID 39321430
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus
StudyYin Y et al. 2022Pharmacological researchPMID 34798268
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes
StudyLi X et al. 2025Redox biologyPMID 40403491
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
StudyKim KH et al. 2018Cell metabolismPMID 29983246
MOTS-c Functionally Prevents Metabolic Disorders
ReviewGao Y et al. 2023MetabolitesPMID 36677050
MOTS-c: Magical Molecule for Diabetic Cardiomyopathy?
StudyYerra VG et al. 2025Cardiovascular drugs and therapyPMID 40172798
MOTS-c modulates skeletal muscle function by directly binding and activating CK2
StudyKumagai H et al. 2024iSciencePMID 39559755
MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus
ReviewBenayoun BA et al. 2019BioEssays : news and reviews in molecular, cellular and developmental biologyPMID 31378979
MOTS-c promotes muscle differentiation in vitro
StudyGarcía-Benlloch S et al. 2022PeptidesPMID 35842023
Role of MOTS-c in the regulation of bone metabolism
ReviewYi X et al. 2023Frontiers in physiologyPMID 37200834
Research areas
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This page is a bibliographic reference for research professionals. It is educational only, it is not medical, clinical, or legal advice, and it is not a recommendation to use any compound. Peptide research is an evolving field: counts and conclusions change as new work is published. Readers are responsible for evaluating the primary literature themselves and for consulting qualified professionals in their own jurisdiction.