Metabolic research
NNMT inhibitors (5-Amino-1MQ)
Published reviews describe inhibition of the enzyme nicotinamide N-methyltransferase (NNMT) and its role in cellular metabolism. Note that the indexed literature treats this as a small molecule, not a peptide.
What PubMed contains
Each figure links to the query that produced it. Where a count is zero, the published evidence of that kind was absent from the index at the retrieval date — a fact about the literature, not a judgement of ours.
Selected literature
Published work on NNMT inhibitors (5-Amino-1MQ)
Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target
ReviewSun WD et al. 2024International immunopharmacologyPMID 39312861
Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model
StudyLi S et al. 2025Pharmacological researchPMID 40484359
Mechanisms and inhibitors of nicotinamide N-methyltransferase
ReviewIyamu ID et al. 2021RSC medicinal chemistryPMID 34458733
Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target
ReviewJawaria et al. 2025BiomoleculesPMID 41008588
Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy
ReviewLi XY et al. 2022Frontiers in oncologyPMID 35756670
Nicotinamide N -methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma
StudyLi Y et al. 2023Hepatology (Baltimore, Md.)PMID 36633260
Nicotinamide N-methyltransferase in cardiovascular Diseases: Mechanistic insights and therapeutic potential
ReviewBi SZ et al. 2025European journal of medicinal chemistryPMID 40412299
Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions
ReviewLi JJ et al. 2024MetabolitesPMID 38921477
Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes
ReviewLiu JR et al. 2021BioMed research internationalPMID 34368359
Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets
ReviewLai SY et al. 2025BiomoleculesPMID 40427612
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation
ReviewRoberti A et al. 2021Molecular metabolismPMID 33453420
Nicotinamide N-Methyltransferase in Head and Neck Tumors: A Comprehensive Review
ReviewTogni L et al. 2021BiomoleculesPMID 34827592
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This page is a bibliographic reference for research professionals. It is educational only, it is not medical, clinical, or legal advice, and it is not a recommendation to use any compound. Peptide research is an evolving field: counts and conclusions change as new work is published. Readers are responsible for evaluating the primary literature themselves and for consulting qualified professionals in their own jurisdiction.