Immune research
ARA 290 / cibinetide
Trial reports describe an 11-amino-acid peptide derived from the helix B region of erythropoietin, designed to engage the innate repair receptor without the red-blood-cell-producing (erythropoietic) activity of the parent hormone.
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Selected literature
Published work on ARA 290 / cibinetide
The time to develop treatments for diabetic neuropathy
ReviewRendell MS 2021Expert opinion on investigational drugsPMID 33423557
A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema
StudyLois N et al. 2020Journal of clinical medicinePMID 32674280
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
StudyNairz M et al. 2017Scientific reportsPMID 29026145
ARA 290 for treatment of small fiber neuropathy in sarcoidosis
Reviewvan Velzen M et al. 2014Expert opinion on investigational drugsPMID 24555851
Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand
StudyYao M et al. 2020TransplantationPMID 32345869
Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation
StudyYao M et al. 2021Cell transplantationPMID 34498509
Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes
StudyBitto A et al. 2018Biochimica et biophysica acta. Molecular basis of diseasePMID 29223734
Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression
StudyAl-Onaizi MA et al. 2022Brain, behavior, and immunityPMID 34343617
The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice
StudyAwida Z et al. 2021International journal of molecular sciencesPMID 35008482
Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain
Clinical trialCulver DA et al. 2017Investigative ophthalmology & visual sciencePMID 28475703
Managing fatigue in sarcoidosis - A systematic review of the evidence
ReviewAtkins C et al. 2017Chronic respiratory diseasePMID 27507833
ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception
StudyZhang W et al. 2016PeptidesPMID 26774587
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This page is a bibliographic reference for research professionals. It is educational only, it is not medical, clinical, or legal advice, and it is not a recommendation to use any compound. Peptide research is an evolving field: counts and conclusions change as new work is published. Readers are responsible for evaluating the primary literature themselves and for consulting qualified professionals in their own jurisdiction.