Neuroactive research
Semax
Published work describes an ACTH(4-10) analogue — a modified fragment of the hormone ACTH — and reports effects on the expression of neurotrophic (nerve-supporting) factors.
What PubMed contains
Each figure links to the query that produced it. Where a count is zero, the published evidence of that kind was absent from the index at the retrieval date — a fact about the literature, not a judgement of ours.
Selected literature
Published work on Semax
Functional Connectomic Approach to Studying Selank and Semax Effects
StudyPanikratova YR et al. 2020Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsPMID 32342318
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
StudyLiu R et al. 2025British journal of pharmacologyPMID 40692165
Pharmacological Aspects of Neuro-Immune Interactions
ReviewTarasov VV et al. 2018Current pharmaceutical designPMID 28875850
ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke
StudyFilippenkov IB et al. 2024BiomedicinesPMID 39767736
Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties
StudyMagrì A et al. 2016Journal of inorganic biochemistryPMID 27586814
Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage
StudyFilippenkov IB et al. 2025International journal of molecular sciencesPMID 40650034
[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]
Clinical trialGusev EI et al. 2018Zhurnal nevrologii i psikhiatrii imeni S.S. KorsakovaPMID 29798983
Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases
ReviewGiri S et al. 2025NeuropeptidesPMID 41004910
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
StudyMedvedeva EV et al. 2014BMC genomicsPMID 24661604
The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease
StudyRadchenko AI et al. 2025Acta naturaePMID 41479572
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia
StudyDmitrieva VG et al. 2010Cellular and molecular neurobiologyPMID 19633950
[POSSIBLE ROLE OF TRANSTHYRETIN IN THE BIOLOGICAL MECHANISM OF THE REGULATORY PEPTIDE NEUROPROTECTION.]
ReviewVyunova TV et al. 2016Molekuliarnaia genetika, mikrobiologiia i virusologiiaPMID 30383932
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