Growth axis research
GHRH analogues & ghrelin receptor agonists
Published pharmacology describes two distinct mechanisms — activation of the GHRH receptor (sermorelin, CJC-1295) and selective activation of the ghrelin receptor (ipamorelin) — both reported to raise growth hormone secretion.
What PubMed contains
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Selected literature
Published work on GHRH analogues & ghrelin receptor agonists
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Clinical trialTeichman SL et al. 2006The Journal of clinical endocrinology and metabolismPMID 16352683
Ipamorelin, the first selective growth hormone secretagogue
StudyRaun K et al. 1998European journal of endocrinologyPMID 9849822
Advances in the detection of growth hormone releasing hormone synthetic analogs
StudyMemdouh S et al. 2021Drug testing and analysisPMID 34665524
Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions
ReviewVan Hout MC et al. 2016Substance use & misusePMID 26771670
A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS
StudyTimms M et al. 2019Drug testing and analysisPMID 30938069
Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives
ReviewRenke G et al. 2026International journal of molecular sciencesPMID 42123471
Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
ReviewMavrych V et al. 2026Frontiers in agingPMID 42021992
An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma
StudyTimms M et al. 2019Drug testing and analysisPMID 30489688
Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?
StudyWalker RF 2006Clinical interventions in agingPMID 18046908
Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples
StudyCristea CD et al. 2023Analytical biochemistryPMID 37806509
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review
ReviewCoutinho LFD et al. 2026The Journal of sports medicine and physical fitnessPMID 41880199
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
StudyAlba M et al. 2006American journal of physiology. Endocrinology and metabolismPMID 16822960
Research areas
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Others indexed under growth axis research
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This page is a bibliographic reference for research professionals. It is educational only, it is not medical, clinical, or legal advice, and it is not a recommendation to use any compound. Peptide research is an evolving field: counts and conclusions change as new work is published. Readers are responsible for evaluating the primary literature themselves and for consulting qualified professionals in their own jurisdiction.